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Comparing Genes, Proteins, and Genomes (Bioinformatics III)

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Course Features

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Duration

22 hours

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Delivery Method

Online

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Available on

Limited Access

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Accessibility

Mobile, Desktop, Laptop

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Language

English

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Subtitles

English

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Level

Beginner

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Teaching Type

Self Paced

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Video Content

22 hours

Course Description

Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different.

In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST.

Course Overview

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Hands-On Training,Instructor-Moderated Discussions

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Case Studies, Captstone Projects

Skills You Will Gain

What You Will Learn

You will gain knowledge on bioinformatics

You will gain knowledge on graph theory

You will gain knowledge on bioinformatics algorithms

You will gain knowledge on python programming

Course Instructors

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Pavel Pevzner

Department of Computer Science and Engineering

Pavel Pevzner is the instructor for this course
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Phillip Compeau

Department of Computer Science & Engineering

Phillip Compeau is a visiting researcher at UC San Diego. He is an Associate Teaching Professor and the Assistant Department Head for Education in the Computational Biology Department at Carnegie Mel...
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Nikolay Vyahhi

Department of Computer Science and Engineering

Nikolay Vyahhi is a Visiting Scholar in the Department of Computer Science and Engineering at University of California San Diego (UCSD). Together with Phillip Compeau, he co-founded Rosalind, a free ...

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